Ratchet and Clank are captured and forced to compete on an underground reality combat sport show. The show, which features abducted heroes fighting for their lives against a gruesome gang of deadly Exterminators, is run by a deranged media mogul named Gleeman Vox, who intends to use Ratchet and Clank as his next contestants.
It doesn't take Vox long to realize that Ratchet is the most promising contestant the show has ever seen. Vox subjects our hero to a series of deadly battles and elaborate games of death, much to the delight of the show's enormous audience.
To keep himself and his friends alive, Ratchet has no choice but to participate in the games and keep driving up the show's ratings with spectacular victories - at least until our heroes can figure out a way to break free from Vox's control and bring the mighty Vox Network crashing down.