Cabela's Big Game Hunter takes the player to six international hotspots in an attempt to acquire prize big game trophies such as grizzly bears, mountain lions, elk, moose, caribou, etc. Such locations consist of New Zealand, Africa, Argentina, the Western United States and even British Columbia. Player can also hunt small game as well as bird hunting such as geese, duck and quail.

Authentic Cabela's equipment can be used such as clothing, tree and ground stands, lure attractants and calls as well as powerful weaponry consisting from rifles to shotguns and pistols. Players must also adhere to real life local hunting regulations such as bag limits, time limits and protected species. Breaking these regulations could result in a penalization and if continued can end the level as well as the game.