The sequel to Hitman forces a retired assassin back into action by treason. Visit the dark recesses of the world corrupted by crime, greed, degradation, and dishonor. Your contracts will take you to exotic locations around the globe including Sicily, St. Petersburg, Japan, Malaysia, and India. A diverse arsenal of equipment, from armor-piercing rifles and explosives to chloroform and poison darts, are at your disposal. Stalk and eliminate your targets up close and personal, in either first- or third-person perspectives. You must decide whether to use stealth or aggression, but be careful--you'll have to deal with the consequences.

In the game, players assume the role of an assassin known as Agent 47. The game advances as players carry out contract killings by solving puzzles to arrange for stealthy, untraceable assassinations.